Presentation on theme: "As food travels through the digestive system, it is exposed to a variety of pH levels. The stomach has a pH of 2 due to the presence of hydrochloric acid."— Presentation transcript: 1
As food travels through the digestive system, it is exposed to a variety of pH levels. The stomach has a pH of 2 due to the presence of hydrochloric acid (HCl), and the small intestine has a pH ranging from 7 to 9. HCl converts pepsinogen into pepsin, an enzyme that digests proteins in the stomach. Which of the following most likely happens to pepsin as it enters the small intestine? A. It becomes inactive. B. It begins to replicate. C. Its shape changes to engulf large
proteins. D. Its activity increases to digest more proteins. Show
2 Interactive Journal Entry “Enzymes SC.912.L.18.11” 3 Enzymes Slides 3-7 can be gone through very quickly (overview). Slides 8-12 should cover the first portion of the benchmark – do a “check for understanding” at slide 12. Slides should cover the second part of the benchmark.
SC.912.L Explain the role of enzymes as catalysts. Identify factors, such as pH and temperature, and their effect on enzyme activity. 4 Introduction on Enzymes
5 Introduction on Enzymes 6
Introduction on Enzymes 7 Introduction on Enzymes 8 Enzymes Serves as a catalyst (speeds up rate of chemical reactions).
9 Enzymes – What are they made of?
10 Chemical Reaction with an Enzyme 11 Why are Enzymes Important? 12
Enzymes SC.912.L Explain the role of enzymes as catalysts. Identify factors, such as pH and temperature, and their effect on enzyme activity. You should now be able to explain the role of enzymes as catalysts 13
Enzymes SC.912.L Explain the role of enzymes as catalysts. Identify factors, such as pH and temperature, and their effect on enzyme activity. 14 What affects enzyme activity? 15
What affects enzyme activity?
16 As food travels through the digestive system, it is exposed to a variety of pH levels. The stomach has a pH of 2 due to the presence of hydrochloric acid (HCl), and the small intestine has a pH ranging from 7 to 9. HCl converts pepsinogen into pepsin, an enzyme that digests proteins in the stomach. Which of the following most likely happens to pepsin as it enters the small intestine? A. It becomes inactive. B. It begins to
replicate. C. Its shape changes to engulf large proteins. D. Its activity increases to digest more proteins. Give students a chance to change their answer – the next slide will show the answer. Engage in a “Why?” conversation.
17 As food travels through the digestive system, it is exposed to a variety of pH levels. The stomach has a pH of 2 due to the presence of hydrochloric acid (HCl), and the small intestine has a pH ranging from 7 to
9. HCl converts pepsinogen into pepsin, an enzyme that digests proteins in the stomach. Which of the following most likely happens to pepsin as it enters the small intestine? A. It becomes inactive. Why? B. It begins to replicate. C. Its shape changes to engulf large proteins. D. Its activity increases to digest more proteins.
18 You Do Questions The following questions can be projected when an instructor reaches the “You Do” or an
instructor can use the handout. 19 A. Enzymes aid in oxygen acquisition for respiration.
20 Measured amount of glucose What substance gives the stomach its pH of 1 2?Pepsin is a stomach enzyme that serves to digest proteins found in ingested food. Gastric chief cells secrete pepsin as an inactive zymogen called pepsinogen. Parietal cells within the stomach lining secrete hydrochloric acid that lowers the pH of the stomach. A low pH (1.5 to 2) activates pepsin.
When the pH or temperature is changed an enzyme becomes denatured by changing the?Hydrogen Ion Concentration (pH)
Enzymes may be denatured by extreme levels of hydrogen ions (whether high or low); any change in pH, even a small one, alters the degree of ionization of an enzyme's acidic and basic side groups and the substrate components as well.
What happens to the activity of pepsin when it enters the small intestine where the pH is 8?Pepsin works best at a pH of 2. And as the stomach has a very acidic condition, pepsin works well. But in the small intestine, the pH is about 8, which is too high for pepsin to function. Therefore, pepsin gets denatured in the small intestine.
What will happen to the reaction rate if the appropriate enzyme is added to a chemical reaction?The energy required to reach the transition state (the activation energy) constitutes a barrier to the progress of the reaction, limiting the rate of the reaction. Enzymes (and other catalysts) act by reducing the activation energy, thereby increasing the rate of reaction.
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