Can delsym and benadryl be taken together

Common over-the-counter medications like cough suppressants and antihistamines are generally though to be perfectly safe – and if taken as directed, they usually are.

However, even common, seemingly simple drugs like these can have a long list of potentially dangerous interactions with other substances, from herbal supplements to strong prescription opiates. It’s always important to read warning labels and/or speak with a pharmacist or other medical professional before taking two or more medications at a time.

Cough medicine and antihistamines are two of the most commonly purchased over-the-counter medications available. Illnesses that cause coughing like colds and the flu are passed around constantly among the public, and allergies to airborne substances like pet dander and plant pollen are very common afflictions. According to the Asthma and Allergy Foundation of America, around 30 percent of adults and 40 percent of children in the US have an allergy to at least one thing. These individuals may need antihistamines to make it through the day, especially during peak allergy seasons.

Health Risks

Can delsym and benadryl be taken together

One problem with over-the-counter medications is that one bottle can contain multiple different substances, some of which can be easily overlooked. If people don’t take the time to look through the warnings every time they purchase one of these medications, they can end up putting themselves at risk.

Some antihistamines come with painkiller or decongestant ingredients to combat multiple allergy symptoms. If a person who purchases this kind of medication doesn’t pay attention and takes additional painkillers or decongestants on top of it, this can cause a dangerous situation. If both of the painkillers are of the acetaminophen variety, an individual could overdose and end up causing damage to the liver. Ibuprofen overdoses can cause stomach bleeding and intestinal damage.

Many cough medicines also contain painkillers and decongestants. It’s very important to read the bottle before taking an over-the-counter medication, even if you think you’ve taken it before. Companies often release new varieties of their medicines that contain new elements to be more effective, and these added ingredients could interact with your other medications. It’s easy to grab a similar looking bottle that actually contains different ingredient than you’re used to without noticing.

When it comes to cough medicines, there are special risks to consider if the drug contains codeine. Codeine is an opiate used to treat pain, diarrhea, and coughing, and it is therefore a popular ingredient in cough medicine. Because opiate abuse can cause a pleasant high, cough syrup containing codeine became very popular for abuse until the government began to regulate it more strictly, requiring it to be kept behind the pharmacy counter and tracking how much each individual shopper purchases.

Side effects of codeine include:

  • Drowsiness
  • Constipation
  • Blurred vision
  • Fever
  • Dizziness
  • Nausea or vomiting
  • Appetite changes
  • Headache
  • Itching
  • Insomnia
  • Blurred vision
  • Shortness of breath
  • Fast, irregular, or weak pulse

Many of these side effects can interfere with people’s ability to operate heavy machinery such as vehicles.


Combined with the notorious tendency of antihistamines to cause drowsiness, anyone who combines cough medicine and allergy medication, even if they are otherwise safe, should avoid driving.


Due to the number of different over-the-counter medications currently on the market today, it can be very difficult to keep track of what interacts with what. Your best bet is to speak to a doctor or pharmacist any time you need to take two or more medications at once, no matter how safe they may seem.

You aren't alone. You deserve to get help.

Desert Hope is located in Las Vegas, Nevada, which is easily accessible from most locations in the Southwest. We offer a full continuum of care that spans from inpatient medical detox and rehab to outpatient services and sober living. Take the next step toward recovery: learn more about our addiction treatment programs near Vegas or learn about how rehab is affordable for everyone.

Your Next Steps
Recovery is possible. We're here to help with your addiction.

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Very Serious. These medicines may interact and cause very harmful effects and are usually not taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Monoamine oxidase inhibitors (MAOIs) may increase the effects of your antihistamine.

What might happen:

Your blood pressure may drop dangerously low.

What you should do about this interaction:

Let your healthcare professionals (e.g. doctor or pharmacist) know right away that you are taking these medicines together. Your doctor may want to change your medicine. Let your doctor know right away if you have any weakness, dizziness, fainting, or blurred vision.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

View Reference

Free RX Coupon

Save up to 80% on your prescriptions.

Available coupons

Save up to 80% on your prescription with WebMDRx

You Might Also Like

View More

  • List Delsym Cough-Cold Oral side effects by likelihood and severity
  • Who should not take Delsym Cough-Cold Oral?
  • Does Delsym Cough-Cold Oral interact with other medications?
  • Should I avoid certain foods while taking Delsym Cough-Cold Oral?
  • What should I know regarding pregnancy, nursing and administering Delsym Cough-Cold Oral to children or the elderly?
  • What conditions does Delsym Cough-Cold Oral treat?

  • Common Searches
  • Adderall
  • Celexa
  • Cipro
  • Cymbalta
  • Flexeril
  • Hydrocodone
  • Prilosec
  • Prozac
  • Seroquel
  • Synthroid
  • Tramadol
  • Trazodone
  • Lexapro
  • Lisinopril
  • Mobic
  • Naproxen
  • Neurontin
  • Pradaxa
  • Prednisone
  • Vicodin
  • Warfarin
  • Wellbutrin
  • Xanax
  • Zocor
  • Zoloft

Drug Survey

Have you ever purchased Delsym Cough-Cold Oral?

Yes, In the past 3 months

Yes, In the past 6 months

Yes, In the past year

Haven't purchased but considering

Don't plan to purchase

This survey is being conducted by the WebMD marketing sciences department.

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

Can I take allergy medicine with delsym?

No interactions were found between Delsym 12 Hour Cough Relief and Zyrtec. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Can you take Benadryl and cough medicine at the same time?

What Issues Are There from Combining Cough Medicine & Antihistamines? Common over-the-counter medications like cough suppressants and antihistamines are generally though to be perfectly safe – and if taken as directed, they usually are.

Can a toddler take delsym and Benadryl?

Children under 2 years of age should not be given any kind of cough and cold product that contains a decongestant or antihistamine because serious and possibly life-threatening side effects could occur. Reported side effects of these products included convulsions, rapid heart rates and death.

Can I give my 5 year old Benadryl and delsym?

Delsym contains only a cough suppressant and is safe to give with other over-the-counter or prescription allergy medications your child may be taking. Dosage: Every 12 hours. ... DELSYM COUGH SUPPRESSANT 12 HOUR..