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Sponsor: Collaborators: Information provided by (Responsible Party): Chris McIntyre, Lawson Health Research Institute Brief Summary: Shortness of breath is very common among patients on dialysis for kidney failure; however, its causes are often not understood. This study will explore the lungs and the heart of these patients to determine the causes of shortness of breath. The amount of salt in the body tissues, which tends to accumulate in dialysis patients and can also cause shortness of breath, will also be measured. Machines that exploit magnetic resonance, ultrasound and x-rays to take images of the body interior will be employed; in addition, breathing tests, questionnaires and blood tests will also be used. 20 patients on dialysis will be recruited and have two visits: one at the beginning of the study and one year later to observe any changes in the lungs, heart and salt accumulation over time.
Resource links provided by the National Library of Medicine
Primary Outcome Measures :
Secondary Outcome Measures :
Biospecimen Retention: Samples Without DNA Plasma and serum. Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies. Layout table for eligibility information
The patients for this trial will be recruited from incident and prevalent hemodialysis patients receiving care for their kidney disease from the Dialysis Service at London Health Sciences Centre, London Ontario. Up to 20 eligible patients will be recruited. Inclusion Criteria:
Exclusion Criteria
Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03773991 Layout table for location information
Lawson Health Research Institute University of Western Ontario, Canada Western University, Canada Layout table for investigator information
Bolignano D, Rastelli S, Agarwal R, Fliser D, Massy Z, Ortiz A, Wiecek A, Martinez-Castelao A, Covic A, Goldsmith D, Suleymanlar G, Lindholm B, Parati G, Sicari R, Gargani L, Mallamaci F, London G, Zoccali C. Pulmonary hypertension in CKD. Am J Kidney Dis. 2013 Apr;61(4):612-22. doi: 10.1053/j.ajkd.2012.07.029. Epub 2012 Nov 17. Review. Erratum in: Am J Kidney Dis. 2015 Mar;65(3):524. Plesner LL, Warming PE, Nielsen TL, Dalsgaard M, Schou M, Høst U, Rydahl C, Brandi L, Køber L, Vestbo J, Iversen K. Chronic obstructive pulmonary disease in patients with end-stage kidney disease on hemodialysis. Hemodial Int. 2016 Jan;20(1):68-77. doi: 10.1111/hdi.12342. Epub 2015 Aug 5. Layout table for additonal information
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Keywords provided by Chris McIntyre, Lawson Health Research Institute:
Additional relevant MeSH terms: Layout table for MeSH terms
Why do CKD patients have shortness of breath?Fatigue or weakness — a build-up of wastes or a shortage of red blood cells (anemia) can cause these problems when the kidneys begin to fail. Shortness of breath — kidney failure is sometimes confused with asthma or heart failure, because fluid can build up in the lungs.
Does chronic kidney disease affect your breathing?The lungs may be severely affected by advanced chronic kidney disease (CKD) [3]; however, the prevalence of lung dysfunction is increased even in patients with CKD stage 1-4, to 10% for restrictive and 16% for obstructive lung function according to the National Health and Nutrition Examination Survey (NHANES) 2007-2012 ...
What is the new treatment for CKD?FDA has approved Kerendia (finerenone) tablets to reduce the risk of kidney function decline, kidney failure, cardiovascular death, non-fatal heart attacks, and hospitalization for heart failure in adults with chronic kidney disease associated with type 2 diabetes.
Is shortness of breath normal for dialysis patients?Shortness of breath is very common among patients on dialysis for kidney failure; however, its causes are often not understood. This study will explore the lungs and the heart of these patients to determine the causes of shortness of breath.
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