What is the safest flea tick and heartworm medication for dogs

Best Overall Flea Medicine for Dogs Veterinarians recommend Simparica Trio because of its effective protection against ticks and fleas, as well as heartworms, roundworms, and hookworms—all in one convenient monthly chew. It's a small, liver-flavored chewable tablet available by prescription.

Both products are safe for dogs when following directions and have been approved by the FDA to treat and prevent flea and tick infestations. While Simparica was trialed and not approved, Nexgard has not yet been evaluated for use in breeding, pregnant, or lactating dogs.

Trifexis is one of the leading oral combination heartworm preventatives. It is a once a month chewable tablet that prevents heartworms, kills adult fleas and also prevents hookworms, roundworms and whipworms. Sentinel Spectrum does the same, with the added benefit of preventing tapeworms.